/* Copyright (C) 2017 Genome Research Ltd. Author: Petr Danecek Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions: The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software. THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. */ /* Reorder duplicate lines so that compatible variant types are returned together by bcf_sr_next_line() - readers grouped by variants. Even with many readers there will be typically only several groups */ #ifndef __BCF_SR_SORT_H__ #define __BCF_SR_SORT_H__ #include "htslib/synced_bcf_reader.h" #include "htslib/kbitset.h" typedef struct { int nrec, mrec; bcf1_t **rec; } vcf_buf_t; typedef struct { char *str; // "A>C" for biallelic records or "A>C,A>CC" for multiallelic records int type; // VCF_SNP, VCF_REF, etc. int nalt; // number of alternate alleles in this record int nvcf, mvcf, *vcf; // the list of readers with the same variants bcf1_t **rec; // list of VCF records in the readers kbitset_t *mask; // which groups contain the variant } var_t; typedef struct { char *key; // only for debugging int nvar, mvar, *var; // the variants and their type int nvcf; // number of readers with the same variants } grp_t; typedef struct { int nvar, mvar, *var; // list of compatible variants that can be output together int cnt; // number of readers in this group kbitset_t *mask; // which groups are populated in this set (replace with expandable bitmask) } varset_t; typedef struct { uint8_t score[256]; int nvar, mvar; var_t *var; // list of all variants from all readers int nvset, mvset; int mpmat, *pmat; // pairing matrix, i-th vset and j-th group accessible as i*ngrp+j int ngrp, mgrp; int mcnt, *cnt; // number of VCF covered by a varset grp_t *grp; // list of VCF representatives, each with a unique combination of duplicate lines varset_t *vset; // list of variant sets - combinations of compatible variants across multiple groups ready for output vcf_buf_t *vcf_buf; // records sorted in output order, for each VCF bcf_srs_t *sr; void *grp_str2int; void *var_str2int; kstring_t str; int moff, noff, *off, mcharp; char **charp; const char *chr; int pos, nsr, msr; int pair; int nactive, mactive, *active; // list of readers with lines at the current pos } sr_sort_t; sr_sort_t *bcf_sr_sort_init(sr_sort_t *srt); void bcf_sr_sort_reset(sr_sort_t *srt); int bcf_sr_sort_next(bcf_srs_t *readers, sr_sort_t *srt, const char *chr, int pos); int bcf_sr_sort_set_active(sr_sort_t *srt, int i); int bcf_sr_sort_add_active(sr_sort_t *srt, int i); void bcf_sr_sort_destroy(sr_sort_t *srt); void bcf_sr_sort_remove_reader(bcf_srs_t *readers, sr_sort_t *srt, int i); #endif