{-# LANGUAGE DeriveDataTypeable #-} {-# LANGUAGE NoMonomorphismRestriction #-} {-# LANGUAGE RecordWildCards #-} {-# LANGUAGE RankNTypes #-} {-# LANGUAGE FlexibleContexts #-} -- | Visualize detailed comparsions of HMMER3 models -- For more information on Infernal consult module Main where import Bio.HMMCompareResult import Bio.HMMDraw import qualified Bio.HMMParser as HM import System.Console.CmdArgs import Data.Either import qualified Data.Either.Unwrap as E import System.Directory import qualified Bio.StockholmParser as SP import Paths_cmv (version) import Data.Version (showVersion) import Data.List (intercalate) import Control.Monad import Data.Maybe options :: Options data Options = Options { hmmCompareResultFile :: String, modelsFile :: String, alignmentFile :: String, modelDetail :: String, emissionLayout :: String, alignmentEntries :: Int, maxWidth :: Double, scalingFactor :: Double, transitionCutoff :: Double, comparisonAlignment :: String, outputFormat :: String, outputDirectoryPath :: String, modelNameToggle :: Bool } deriving (Show,Data,Typeable) options = Options { hmmCompareResultFile = def &= name "r" &= help "Path to HMMCompare result file", modelsFile = def &= name "m" &= help "Path to covariance model file", alignmentFile = "" &= name "s" &= help "Path to stockholm alignment file", modelDetail = "detailed" &= name "d" &= help "Set verbosity of drawn models: minimal, simple, detailed", emissionLayout = "box" &= name "e" &= help "Set layout of drawn models: score, probability, box (Default: box)", alignmentEntries = (50 :: Int) &= name "n" &= help "Set cutoff for included stockholm alignment entries (Default: 50)", maxWidth = (55 :: Double) &= name "w" &= help "Set maximal width of result figure (Default: 100)", scalingFactor = (2 :: Double) &= name "c" &= help "Set uniform scaling factor for image size (Default: 2)", transitionCutoff = (0.01 :: Double) &= name "t" &= help "Minimal value for a transition probability to be displayed (Default: 0.01)", comparisonAlignment = "model" &= name "a" &= help "Set layout of drawn models: model, comparison", outputFormat = "pdf" &= name "f" &= help "Output image format: pdf, svg, png, ps (Default: pdf)", outputDirectoryPath = "" &= name "p" &= help "Output directory path (Default: none)", modelNameToggle = False &= name "b" &= help "Write all comma separted model names to modelNames file (Default: False)" } &= summary ("HMMCV " ++ toolVersion) &= help "Florian Eggenhofer - 2013-2016" &= verbosity main :: IO () main = do Options{..} <- cmdArgs options --Validate input modelFileExists <- doesFileExist modelsFile hmmCFileExists <- doesFileExist hmmCompareResultFile alnFileExists <- doesFileExist alignmentFile if modelFileExists && hmmCFileExists && alnFileExists then do inputModels <- HM.readHMMER3 modelsFile if isRight inputModels then do let models = E.fromRight inputModels hmmCResultParsed <- getHMMCompareResults hmmCompareResultFile let modelNumber = length models alnInput <- SP.readExistingStockholm alignmentFile Control.Monad.when (isLeft alnInput) $ print (E.fromLeft alnInput) let alns = if isRight alnInput then map (\a -> Just a) (E.fromRight alnInput) else replicate modelNumber Nothing let currentModelNames = map HM.name models currentWD <- getCurrentDirectory let dirPath = if null outputDirectoryPath then currentWD else outputDirectoryPath if and $ map isRight hmmCResultParsed then do let rightHMMCResultsParsed = rights hmmCResultParsed --let outputName = diagramName "hmmcv" outputFormat setCurrentDirectory dirPath let modelFileNames = map (\m -> m ++ "." ++ outputFormat) currentModelNames let alignmentFileNames = map (\m -> m ++ ".aln" ++ "." ++ outputFormat) currentModelNames writeModelNameFile modelNameToggle dirPath currentModelNames let (modelVis,alignmentVis) = unzip $ drawSingleHMMComparison modelDetail alignmentEntries transitionCutoff emissionLayout maxWidth scalingFactor models alns rightHMMCResultsParsed mapM_ (\(a,b) -> printHMM a svgsize b) (zip modelFileNames modelVis) mapM_ (\(alnPath,stockholm) -> if isJust stockholm then printHMM alnPath svgsize (fromJust stockholm) else return ()) (zip alignmentFileNames alignmentVis) setCurrentDirectory currentWD else print (lefts hmmCResultParsed) else print (E.fromLeft inputModels) else do Control.Monad.unless modelFileExists $ putStrLn "Model file not found" Control.Monad.unless hmmCFileExists $ putStrLn "Comparison file not found" toolVersion :: String toolVersion = showVersion version writeModelNameFile :: Bool -> String -> [String] -> IO () writeModelNameFile toggle outputDirectoryPath modelNames = if toggle then do let modelNamesString = intercalate "," modelNames writeFile (outputDirectoryPath ++ "modelNames") modelNamesString else return ()