PMID- 3282489
OWN - NLM
STAT- MEDLINE
DCOM- 19880526
LR  - 20190919
IS  - 0004-0002 (Print)
IS  - 0004-0002 (Linking)
VI  - 17
IP  - 1
DP  - 1988 Feb
TI  - Neuroendocrine response to estrogen and brain differentiation in heterosexuals, 
      homosexuals, and transsexuals.
PG  - 57-75
AB  - Since 1964, we have found positive estrogen feedback to be a relatively 
      sex-specific reaction of the hypothalamo-hypophyseal system in rats as well as in 
      human beings. It is dependent on the estrogen-convertible androgen level during 
      sexual brain differentiation and also on estrogen priming in adulthood. The lower 
      the estrogen-convertible androgen or primary estrogen level during brain 
      differentiation, the higher the evocability of a positive estrogen action on LH 
      secretion in later life. In clinical studies, we induced a positive estrogen 
      feedback luteinizing hormone secretion in most intact homosexual men, in 
      clear-cut contrast to intact heterosexual or bisexual men. In addition, the 
      evocability of a positive estrogen feedback was also demonstrable in most 
      homosexual male-to-female transsexuals in significant contrast to hetero-or 
      bisexual male-to-female transsexuals. The following relations have been found 
      between sex hormone levels during brain differentiation and sex-specific 
      responses in adulthood: (i) Estrogens, which are mostly converted from androgens, 
      are responsible for the sex-specific organization of gonadotropin secretion and 
      hence the evocability of a positive estrogen feedback in later life; (ii) both 
      estrogens and androgens, occurring during brain differentiation, predetermine 
      sexual orientation, and (iii) androgens, without conversion to estrogens, are 
      responsible for the sex-specific organization of gender role behavior. 
      Furthermore, the organization periods for sex-specific gonadotropin secretion, 
      sexual orientation, and gender role behavior are not identical but overlapping. 
      Thus, combinations as well as dissociations between deviation of the 
      neuroendocrine organization of sex-specific gonadotropin secretion, sexual 
      orientation, and gender role behavior may occur.
FAU - Dörner, G
AU  - Dörner G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Arch Sex Behav
JT  - Archives of sexual behavior
JID - 1273516
RN  - 0 (Estrogens)
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - IM
MH  - Brain/*embryology
MH  - Estrogens/*physiology
MH  - Feedback
MH  - *Homosexuality
MH  - Humans
MH  - Luteinizing Hormone/blood
MH  - Male
MH  - *Sex Differentiation
MH  - Transsexualism/*blood
RF  - 64
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
AID - 10.1007/BF01542052 [doi]
PST - ppublish
SO  - Arch Sex Behav. 1988 Feb;17(1):57-75. doi: 10.1007/BF01542052.